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Inhibitory Effects of Substrate and Product on the Carvone Biotransformation Activity of Rhodococcus Erythropolis

Inhibitory Effects of Substrate and Product on the Carvone Biotransformation Activity of Rhodococcus Erythropolis

Jenna L E Morrish, Andrew J Daugulis

Biotechnol Lett. 2008 Jul;30(7):1245-50.

PMID: 18327538

Abstract:

The aqueous substrate and product toxicity thresholds in the microbial biotransformation of (-)-trans-carveol to the fragrance/flavor compound (R)-(-)-carvone by Rhodococcus erythropolis were determined. Above aqueous phase concentrations of approx. 500 mg carveol/l and 200-600 mg carvone/l, the biotransformation activity of the biocatalyst was inhibited. This biotransformation was undertaken in a single aqueous phase 3 l [corrected] reactor in which a total of 5 ml carveol (mixture of isomers) was added before the biotransformation rate decreased significantly. The carvone volumetric productivity was 31 mg/lh. Although the growth of the organism post-exposure was not affected, dramatic morphological changes in response to the accumulation of the inhibitory substrate and product were observed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP99489	(−)-Carveol, mixture of isomers		99-48-9	Price

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