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Inhibitory Effects on Mushroom Tyrosinase by Some Alkylbenzaldehydes

Inhibitory Effects on Mushroom Tyrosinase by Some Alkylbenzaldehydes

Qing-Xi Chen, Kang-Kang Song, Qin Wang, Huang Huang

J Enzyme Inhib Med Chem. 2003 Dec;18(6):491-6.

PMID: 15008513

Abstract:

The inhibition kinetics on the diphenolase activity of mushroom tyrosinase by some alkylbenzaldehydes has been investigated. The results show that the alkylbenzaldehydes assayed can lead to reversible inhibition to the enzyme; o-tolualdehyde and m-tolualdehyde are mixed-type inhibitors and p-alkylbenzaldehydes are uncompetitive inhibitors. For the p-alkylbenzaldehydes, the inhibition potency follows the order: p-tolualdehyde < p-ethylbenzaldehyde < p-propylbenzaldehyde = p-Isopropylbenzaldehyde < p-tert-butylbenzaldehyde = p-butylbenzaldehyde < p-pentylbenzaldehyde < p-hexylbenzaldehyde > p-heptylbenzaldehyde > p-octylbenzaldehyde, indicating the hydrophobic p-alkyl group played an important role in inhibition to the enzyme. The inhibitory effects of alkylbenzaldehydes on the monophenolase activity have also been studied. The results show that o-tolualdehyde and m-tolualdehyde can lengthen the lag time and decrease the steady-state activity of the enzyme, but p-alkylbenzaldehydes only decrease the steady-state activity and do not lengthen the lag time, indicating that their inhibitory mechanisms are different.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP104870	p-Tolualdehyde		104-87-0	Price

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