Home
Resources
Publications
Injectable Dynamic Covalent Hydrogels of Boronic Acid Polymers Cross-Linked by Bioactive Plant-Derived Polyphenols

Injectable Dynamic Covalent Hydrogels of Boronic Acid Polymers Cross-Linked by Bioactive Plant-Derived Polyphenols

Zhuojun Huang, Peyman Delparastan, Patrick Burch, Jing Cheng, Yi Cao, Phillip B Messersmith

Biomater Sci. 2018 Aug 21;6(9):2487-2495.

PMID: 30069570

Abstract:

We report here the development of hydrogels formed at physiological conditions using PEG (polyethylene glycol) based polymers modified with boronic acids (BAs) as backbones and the plant derived polyphenols ellagic acid (EA), epigallocatechin gallate (EGCG), tannic acid (TA), nordihydroguaiaretic acid (NDGA), rutin trihydrate (RT), rosmarinic acid (RA) and carminic acid (CA) as linkers. Rheological frequency sweep and single molecule force spectroscopy (SMFS) experiments show that hydrogels linked with EGCG and TA are mechanically stiff, arising from the dynamic covalent bond formed by the polyphenol linker and boronic acid functionalized polymer. Stability tests of the hydrogels in physiological conditions revealed that gels linked with EA, EGCG, and TA are stable. We furthermore showed that EA- and EGCG-linked hydrogels can be formed via in situ gelation in pH 7.4 buffer, and provide long-term steady state release of bioactive EA. In vitro experiments showed that EA-linked hydrogel significantly reduced the viability of CAL-27 human oral cancer cells via gradual release of EA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7931168	(8-Methoxy-2-methylquinolin-5-yl)boronic acid trihydrate			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: