Home
Resources
Publications
Insights Into the Use of Gadolinium and gadolinium/boron-based Agents in Imaging-Guided Neutron Capture Therapy Applications

Insights Into the Use of Gadolinium and gadolinium/boron-based Agents in Imaging-Guided Neutron Capture Therapy Applications

Annamaria Deagostino, Nicoletta Protti, Diego Alberti, Paolo Boggio, Silva Bortolussi, Saverio Altieri, Simonetta Geninatti Crich

Future Med Chem. 2016 May;8(8):899-917.

PMID: 27195428

Abstract:

Gadolinium neutron capture therapy (Gd-NCT) is currently under development as an alternative approach for cancer therapy. All of the clinical experience to date with NCT is done with (10)B, known as boron neutron capture therapy (BNCT), a binary treatment combining neutron irradiation with the delivery of boron-containing compounds to tumors. Currently, the use of Gd for NCT has been getting more attention because of its highest neutron cross-section. Although Gd-NCT was first proposed many years ago, its development has suffered due to lack of appropriate tumor-selective Gd agents. This review aims to highlight the recent advances for the design, synthesis and biological testing of new Gd- and B-Gd-containing compounds with the task of finding the best systems able to improve the NCT clinical outcome.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12008069	Gadolinium boride		12008-06-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: