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Insulin-loaded Hydroxypropyl Methyl Cellulose-Co-Polyacrylamide-Co-Methacrylic Acid Hydrogels Used as Rectal Suppositories to Regulate the Blood Glucose of Diabetic Rats

Insulin-loaded Hydroxypropyl Methyl Cellulose-Co-Polyacrylamide-Co-Methacrylic Acid Hydrogels Used as Rectal Suppositories to Regulate the Blood Glucose of Diabetic Rats

Yongli Shi, Jintao Xue, Yajun Sang, Xiaoqing Xu, Qing Shang

Int J Biol Macromol. 2019 Jan;121:1346-1353.

PMID: 30208299

Abstract:

The purpose of this study was developing a novel hydroxypropyl methyl cellulose-co-polyacrylamide-co-methacrylic acid (HPMC-co-PAM-co-PMAA) hydrogel, which was used as rectal suppository to regulate the blood glucose of diabetes. HPMC-co-PAM-co-PMAA hydrogel was fabricated via free-radical polymerization. Fourier transform infrared spectroscopy (FTIR) and Raman spectra were used to confirm the fabrication of HPMC-co-PAM-co-PMAA hydrogel. Their inner morphology was observed with scanning electron microscope (SEM). The extracts of hydrogel were applied to study their cell viability. The hypoglycemic effects of insulin (INS)-loaded HPMC-co-PAM-co-PMAA hydrogels were investigated by rectal administration. FTIR and Raman spectra confirmed the obtaining of HPMC-co-PAM-co-PMAA hydrogels. Many micro-pores were found in the SEM photograph of HPMC-co-PAM-co-PMAA hydrogels. Cell experiments indicated that HPMC-co-PAM-co-PMAA hydrogel was out of cytotoxicity. In vitro release profiles showed that INS-loaded hydrogel could release INS at a continuous manner in pH 7.4 buffer (rectal conditions). Animal experiments suggested that INS-loaded hydrogel had an obvious hypoglycemic effect. Therefore, as a convenient and economic method of administration, INS-loaded HPMC-co-PAM-co-PMAA hydrogels could be used as rectal suppositories to regulate blood glucose.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004653	(Hydroxypropyl)methyl cellulose		9004-65-3	Price

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