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Interaction Analysis of Commercial Graphene Oxide Nanoparticles With Unicellular Systems and Biomolecules

Interaction Analysis of Commercial Graphene Oxide Nanoparticles With Unicellular Systems and Biomolecules

Brixhilda Domi, Carlos Rumbo, Javier García-Tojal, Livia Elena Sima, Gabriela Negroiu, Juan Antonio Tamayo-Ramos

Int J Mol Sci. 2019 Dec 27;21(1):205.

PMID: 31892228

Abstract:

The ability of commercial monolayer graphene oxide (GO) and graphene oxide nanocolloids (GOC) to interact with different unicellular systems and biomolecules was studied by analyzing the response of human alveolar carcinoma epithelial cells, the yeast Saccharomyces cerevisiae and the bacteria Vibrio fischeri to the presence of different nanoparticle concentrations, and by studying the binding affinity of different microbial enzymes, like the α-l-rhamnosidase enzyme RhaB1 from the bacteria Lactobacillus plantarum and the AbG β-d-glucosidase from Agrobacterium sp. (strain ATCC 21400). An analysis of cytotoxicity on human epithelial cell line A549, S. cerevisiae (colony forming units, ROS induction, genotoxicity) and V. fischeri (luminescence inhibition) cells determined the potential of both nanoparticle types to damage the selected unicellular systems. Also, the protein binding affinity of the graphene derivatives at different oxidation levels was analyzed. The reported results highlight the variability that can exist in terms of toxicological potential and binding affinity depending on the target organism or protein and the selected nanomaterial.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS71741	Graphene oxide nanocolloids			Price

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