Home
Resources
Publications
Interaction of S-methyl Methanethiosulfonate With DPPC Bilayer

Interaction of S-methyl Methanethiosulfonate With DPPC Bilayer

María E Defonsi Lestard, Sonia B Díaz, María E Tuttolomondo, Santiago Sánchez Cortez, Marcelo Puiatti, Adriana B Pierini, Aida Ben Altabef

Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:479-89.

PMID: 22832011

Abstract:

The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS) interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid effect on vesicle stability was studied. The results show that MMTS interacts to different extents with the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states. To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design of their mode of action.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2949920	S-Methyl methanethiosulfonate		2949-92-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: