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[Interaction of Tertiapin, a Neurotoxin From Bee Venom, With Calmodulin]

[Interaction of Tertiapin, a Neurotoxin From Bee Venom, With Calmodulin]

A I Miroshnikov, V A Boĭkov, L G Snezhkova, S E Severin, V I Shvets

Bioorg Khim. 1983 Jan;9(1):26-32.

PMID: 6091685

Abstract:

Tertiapin, a neurotoxin from the honey bee venom, interacts specifically with calmodulin in the presence of Ca2+. The nature of this interaction was studied using calmodulin-cAMP phosphodiesterase system. Tertiapin does not affect the unstimulated basal activity of phosphodiesterase. However, it totally inhibits the enzyme-activating capacity of calmodulin. Analysis of the dose-dependent activation of phosphodiesterase by calmodulin in the presence of tertiapin indicated that inhibition is caused by the interaction of two tertiapin molecules with calmodulin (Kd 2 microM). The data obtained suggest that the toxic effect of tertiapin in nervous tissue is mediated by blockade of calmodulin function.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4246960	Tertiapin			Price

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