Home
Resources
Publications
Interactions Between DNA Purines and Ruthenium Ammine Complexes Within Nanostructured Sol-Gel Silica Matrixes

Interactions Between DNA Purines and Ruthenium Ammine Complexes Within Nanostructured Sol-Gel Silica Matrixes

Luís M F Lopes, Ana R Garcia, Pedro Brogueira, Laura M Ilharco

J Phys Chem B. 2010 Mar 25;114(11):3987-98.

PMID: 20196584

Abstract:

The interactions between DNA purines (guanine and adenine) and three ruthenium ammine complexes (hexaammineruthenium(III) chloride, hexaammineruthenium(II) chloride, and ruthenium-red) were studied in a confined environment, within sol-gel silica matrixes. Two encapsulation methods were rehearsed (differing in temperature and condensation pH), in order to analyze the effects of the sol-gel processes on the purines and on the Ru complexes separately. The extent of decomposition of the Ru complexes, as well as the interactions established with the purine bases, proved to be determined by the coencapsulation method. Combined results by diffuse reflectance UV-vis and infrared spectroscopies showed that, when coencapsulation is carried out at 60 degrees C, specific H bonding interactions are established between the amine group of Ade and the ammine groups of the Ru complex or the hydroxo group of an early decomposition product. These are responsible for the important role of the purine in inhibiting the oxidation reactions of the Ru(II) and Ru(III) complexes. In contrast, Gua establishes preferential H bonds with the matrix (mainly due to the carbonyl group), leading to higher yields in the final oxidation products of the Ru complexes, namely, trimers and dimers. Direct covalent bonding of either purine to the metal was not observed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15305723	Hexaammineruthenium(II) chloride		15305-72-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: