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Interactions of 2-methyladenines and poly(m2A) With poly(br5U)

Interactions of 2-methyladenines and poly(m2A) With poly(br5U)

S Higuchi, K Yasui, M Hattori

Nucleic Acids Symp Ser. 1985;(16):13-6.

PMID: 4088857

Abstract:

Mixing curve experiments and melting curve analyses have shown that poly(m2A) forms complexes with poly(br5U) with stoichiometries of either 1:1 or 1:2 in high ionic strengths. CD spectra of poly(m2A).poly(br5U) and poly(m2A).2 poly(br5U) both resemble quite well to those of poly(A). poly(br5U) and poly(A).2poly(br5U), respectively. This suggests that the corresponding complexes are closely related in the structural details. Significant similarities of the CD spectra were observed for poly(m2A).2poly(br5U) and complexes between 2,9-dimethyladenine or 2-methyladenosine and poly(br5U) in the presence of spermine, indicating also the 1:2 stoichiometry. Thus, a methyl group at the position 2 of adenine ring is not necessarily hindering a formation of the Watson-Crick type base pairings.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25988403	Poly(2-vinylthiophene)		25988-40-3	Price

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