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Interactions of Nonprotic Organic Solvents With [val5]angiotensin in Water

Interactions of Nonprotic Organic Solvents With [val5]angiotensin in Water

Robert C Neuman Jr, John T Gerig

J Phys Chem B. 2011 Feb 24;115(7):1712-9.

PMID: 21288004

Abstract:

Intermolecular solvent-solute nuclear Overhauser effects have been used to explore interactions of the organic component of acetonitrile-water, acetone-water, and dimethyl sulfoxide-water mixtures with the peptide hormone [val(5)]angiotensin. As reported by the NOEs, many cross relaxation terms for interactions of these organic cosolvents are adequately accounted for using a hard spheres interaction model in which encounters of peptide and cosolvent molecules take place by mutual diffusion. However, there are indications of localized solvent-peptide interactions that are not well described by this model. In dimethyl sulfoxide-water at 0 °C, organic solvent near the C-terminal Phe8 residue and the Val3 residue produce strongly enhanced cross-relaxation terms. NOEs for all peptide N-H protons and the protons of the Tyr4 aromatic ring were significantly more positive than expected in 33% acetone-water (v/v) at 0 °C, while those for most side-chain protons were close to predictions of the hard sphere model. All peptide-organic solvent NOEs in 35% acetonitrile water (v/v) at 0 °C are consistent with the hard spheres interaction model.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS25304	Solvents in Water			Price

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