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Interleukin-13 Peptide Kinoid Vaccination Attenuates Allergic Inflammation in a Mouse Model of Asthma

Interleukin-13 Peptide Kinoid Vaccination Attenuates Allergic Inflammation in a Mouse Model of Asthma

Qiuping Jing, Tao Yin, Yang Wan, Huashan Shi, Shuntao Luo, Meng Li, Hailong Zhang, Hong He, Shijia Liu, Haoyu Li, Yuquan Wei, Li Yang

Int J Mol Med. 2012 Sep;30(3):553-60.

PMID: 22735668

Abstract:

Asthma is an atopic disorder with increasing frequency and severity in developed nations. Interleukin-13 (IL-13) is one of the most critical mediators of asthma pathology. In the present study, we developed a vaccine comprised of a keyhole limpet hemocyanin-mIL-13 heterocomplex immunogen to persistently neutralize excessive endogenous IL-13. Our results showed that the IL-13 peptide kinoid vaccine could induce sustained and high titer of IL-13-specific IgG when using aluminum hydroxide as an adjuvant, and could suppress the accumulation of eosinophils as well as IL-13 levels in bronchoalveolar lavage fluid (BALF). In addition, total IgE and ovalbumin (OVA)-specific IgE in serum were significantly inhibited. This study also showed that vaccination could prevent airway inflammation and epithelial cell proliferation with goblet cell hyperplasia in a mouse model of acute asthma. In summary, our findings suggest that the IL-13 peptide kinoid can serve as an innovative and effective vaccine against asthma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413347	Interleukin-13 from mouse			Price

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