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Interleukin-17 Inhibition: Role in Psoriasis and Inflammatory Bowel Disease

Interleukin-17 Inhibition: Role in Psoriasis and Inflammatory Bowel Disease

Megan Hohenberger, Leah A Cardwell, Elias Oussedik, Steven R Feldman

J Dermatolog Treat. 2018 Feb;29(1):13-18.

PMID: 28521565

Abstract:

Introduction:
Interleukin 17 (IL-17) antagonism provides a highly effective approach for treating psoriasis. Exacerbations of inflammatory bowel disease have been reported in anti-IL-17 psoriasis trials.
Aim:
To characterize the relationship between IL-17 inhibition and inflammatory bowel disease.
Methods:
A review of English-language articles was performed. Search terms included IL-17, psoriasis, inflammatory bowel disease, secukinumab, ixekizumab and brodalumab.
Results:
IL-17 A inhibition, IL-17RA inhibition and IL-17 knockout led to induction or exacerbation of colitis in mouse models. The placebo groups fared better than the treatment group in controlled trials of anti-IL-17 antibody and anti-IL-17 receptor for Crohn's disease (CD). A brodalumab study (N = 1576) revealed one reported CD case. An ixekizumab study (N = 3736) evaluating moderate-to-severe psoriasis, four patients reported CD and seven reported UC while ixekizumab every 2 weeks led to a moderate exacerbation of UC in one patient and new-onset CD in one patient. A secukinumab study (N = 3430) revealed exposure adjusted incidence rates of 0.11 and 0.15 per 100 patient-years for CD and UC, respectively.
Discussion:
Anti-IL-17 medications are associated with IBD exacerbation. Caution should be used in prescribing these medications in patients with diagnosed IBD or personal history suggestive of IBD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413358	Interleukin-17 from mouse			Price

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