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Interleukin-3 Amplifies Acute Inflammation and Is a Potential Therapeutic Target in Sepsis

Interleukin-3 Amplifies Acute Inflammation and Is a Potential Therapeutic Target in Sepsis

Georg F Weber, Benjamin G Chousterman, Shun He, Ashley M Fenn, Manfred Nairz, Atsushi Anzai, Thorsten Brenner, Florian Uhle, Yoshiko Iwamoto, Clinton S Robbins, Lorette Noiret, Sarah L Maier, Tina Zönnchen, etc.

Science. 2015 Mar 13;347(6227):1260-5.

PMID: 25766237

Abstract:

Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248608	Interleukin-3 from mouse			Price

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