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Interleukin-4 Acts as a Potent Stimulator for Expression of Monocyte Chemoattractant JE/MCP-1 in Mouse Peritoneal Macrophages

H Kikuchi, S Hanazawa, A Takeshita, Y Nakada, Y Yamashita, S Kitano

Biochem Biophys Res Commun. 1994 Aug 30;203(1):562-9.

PMID: 8074704

Abstract:

The recruitment of monocyte/macrophages to inflammatory sites is one of the important events in inflammatory reactions. We show herein that interleukin-4 (IL-4) acts as a potent stimulator for expression of monocyte chemoattractant JE/MCP-1 in mouse peritoneal macrophages. IL-4 induced the JE/MCP-1 gene expression in dose and time dependent fashion. Run-on assay suggests that IL-4 stimulates the JE/MCP-1 gene expression at transcriptional level. Monocyte chemotactic activity was detected in culture medium of the cytokine-treated cells. The chemotactic activity in the culture supernatant was completely neutralized by anti-JE/MCP-1 antiserum.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413105 JE/MCP-1 (CCL2) from mouse JE/MCP-1 (CCL2) from mouse Price
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