Home
Resources
Publications
Interleukin-5 Suppresses Vascular Endothelial Growth Factor-induced Angiogenesis Through STAT5 Signaling

Interleukin-5 Suppresses Vascular Endothelial Growth Factor-induced Angiogenesis Through STAT5 Signaling

Felicitas Bucher, Jungho Lee, Sanghee Shin, Minseok S Kim, Yong-Seok Oh, Sanghoon Ha, Hongkai Zhang, Kyungmoo Yea

Cytokine. 2018 Oct;110:397-403.

PMID: 29921484

Abstract:

Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248610	Interleukin-5 human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: