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International Survey of Apolipoproteins A1 and B Measurements (1983-1984)

International Survey of Apolipoproteins A1 and B Measurements (1983-1984)

G R Cooper, S J Smith, D A Wiebe, M Kuchmak, W H Hannon

Clin Chem. 1985 Feb;31(2):223-8.

PMID: 3917875

Abstract:

We report here results of a worldwide survey of apolipoprotein (apo) A1 and B measurements. A lyophilized pool of human serum was developed for the survey to test its suitability as a candidate Reference Material. Seventy-five laboratories from 18 countries responded to invitations to participate. Using several methods, they evaluated the mass concentration of apo A1 and B in the proposed Reference Material. The bias between laboratories and between analytical methods was then characterized. Fifty-five laboratories reported results before the deadline on measurement of at least one apolipoprotein by one method. Variation in apo A1 and B among collaborators constituted the largest source of error in the study (68% of the total variation for apo A1, 73% for apo B). Variation among method means was not significant for apo A1, but for apo B it constituted 20% of the total variation. Differences due to vials or in replicate measurements within vials were found to constitute 6% or less of the total variability. Within-laboratory, among-vial, and among-replicate CV values were less than 5% for the study. These results suggest that future standardization efforts can be successful.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS37101	Human apolipoprotein A I (mass concentration)			Price

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