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Intestinal Absorption of Amino Acid Derivatives: Structural Requirements for Membrane Hydrolysis

G L Amidon, M Lee, H Lee

J Pharm Sci. 1983 Aug;72(8):943-4.

PMID: 6413676

Abstract:

The intestinal absorption of L-lysine-p-nitroanilide, L-alanine-p-nitroanilide, and glycine-p-nitroanilide was studied in perfused rat intestine in the presence of a variety of potential competitive inhibitors. The results indicate that the hydrolysis site(s) show side-chain specificity, and that inhibitors require a free amino group in the alpha-position and must be in the L-configuration to be effective. Glycyl-L-proline, a peptide transport inhibitor, had no effect on the absorption rate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1205885 Glycine p-nitroanilide Glycine p-nitroanilide 1205-88-5 Price
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