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Intraventricular Pentosan Polysulphate in Human Prion Diseases: An Observational Study in the UK

Intraventricular Pentosan Polysulphate in Human Prion Diseases: An Observational Study in the UK

I Bone, L Belton, A S Walker, J Darbyshire

Eur J Neurol. 2008 May;15(5):458-64.

PMID: 18355301

Abstract:

BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK.
Results:
Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.
Conclusion:
Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP179388659	AH 11110		179388-65-9	Price

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