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[Investigation and Analysis of Occult Hepatitis B Virus Infection Among Voluntary Blood Donors in Lishui Area]

[Investigation and Analysis of Occult Hepatitis B Virus Infection Among Voluntary Blood Donors in Lishui Area]

Yong-Ping Ji, Long-You Zhao, Bin Zhou, Mei-Lian Zhong, Jie Zhuang, Quan Yuan

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Dec;25(6):457-9.

PMID: 22734235

Abstract:

Objective:
Occult hepatitis B infection of voluntary blood donors has been plagued in the serum screening. Determined the OBI through the highly sensitive detection methods Nest-PCR among the blood donors, and then learned occult HBV infection and analysed the genotypes of this area.
Methods:
10 080 serums of donors were determined respectively by the imported Abbott HBsAg kit and Beijing Wantai anti-HBc and anti-HBs reagents, obtained the gene and detected DNA sequences by the high sensitive Nest-PCR method.
Results:
Among 10 080 cases of unpaid blood donors, 108 cases were detected HBsAg positively by Abbott sensitivity kit (positive rate of 1.07%), 767 cases were anti-HBc single - positive (positive rate of 7.67%). 25 patients screened blood donors who tested negative for serum HBsAg and positive for HBV DNA in the 10 080 cases. Occult HBV infection incidence rate was 0.25%. 12 cases were HBV genotype C (48%), 13 cases were genotype B (52%), and no other genotypes. Genotype B has no statistically significant difference to genotype C (P > 0.05). Sequence analysis showed that 5 patients in the HBsAg epitope "a" (aa124 - aa147) have mutation (20%).
Conclusion:
The high proportion of occult hepatitis B infected among voluntary blood donors in our country. Also genotype and mutation was differences in different regions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP393121749	AA147		393121-74-9	Price

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