Home
Resources
Publications
Investigation of Drug Release Modulation From poly(2-oxazoline) Micelles Through Ultrasound

Investigation of Drug Release Modulation From poly(2-oxazoline) Micelles Through Ultrasound

Alice Rita Salgarella, Anna Zahoranová, Petra Šrámková, Monika Majerčíková, Ewa Pavlova, Robert Luxenhofer, Juraj Kronek, Igor Lacík, Leonardo Ricotti

Sci Rep. 2018 Jul 2;8(1):9893.

PMID: 29967422

Abstract:

Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zero-order and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP124825043	Poly(2,6-naphthalenevinylene)		124825-04-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: