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Investigation of heptakis(2,6-di-O-methyl)-beta-cyclodextrin Inclusion Complexes With Flavonoid Glycosides by Electrospray Ionization Mass Spectrometry

Investigation of heptakis(2,6-di-O-methyl)-beta-cyclodextrin Inclusion Complexes With Flavonoid Glycosides by Electrospray Ionization Mass Spectrometry

Zhan Yu, Meng Cui, Cunyu Yan, Fengrui Song, Zhiqiang Liu, Shuying Liu

Rapid Commun Mass Spectrom. 2007;21(5):683-90.

PMID: 17279606

Abstract:

The non-covalent complexes between three flavonoid glycosides (quercitrin, hyperoside and rutin) and heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) were investigated by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS). The 1:1 complexation of each flavonoid glycoside (guest) to the DM-beta-CD (host) was monitored in the negative ion mode by mixing each guest with an up to 30-fold molar excess of the host. The binding constants for all complexes were calculated by a linear equation in the order: DM-beta-CD:quercitrin > DM-beta-CD:rutin > DM-beta-CD:hyperoside. A binding model for the complexes has also been proposed based on the binding constants and tandem mass spectrometric data of these complexes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51166713	Heptakis(2,6-di-O-methyl)-β-cyclodextrin		51166-71-3	Price

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