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Investigation of Lipoic Acid - 4-methoxybenzyl Alcohol Reaction and Evaluation of Its Analytical Usefulness

Monika Turkowicz, Izabella Jastrzebska, Marta Hryniewicka, Urszula Kotowska, Diana Gudalewska, Joanna Karpińska

Food Chem. 2020 Mar 30;309:125750.

PMID: 31704079

Abstract:

The presented work is aimed to synthesize a new UV active derivative of α-lipoic acid (ALA) by its esterification with 4-methoxybenzyl alcohol (4-MBA, anise alcohol). The formation of ester was confirmed by 1HNMR, FTIR and UV spectroscopy. The analytical usefulness of the obtained compound for quantification of ALA in food items was examined using HPLC-UV and GC-MS systems. It was found that it is possible to assay ALA in the ester form in the concentration ranges: 5·10-6-1·10-4 mol L-1 by HPLC-UV and 1∙10-7-5∙10-5 mol L-1 by GC-MS techniques. The GC-MS procedure was applied for the determination of ALA in the food samples.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP105135 4-Methoxybenzyl alcohol 4-Methoxybenzyl alcohol 105-13-5 Price
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