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Investigation of the Cumulative Body Burden of estrogen-3,4-quinone in Breast Cancer Patients and Controls Using Albumin Adducts as Biomarkers

Investigation of the Cumulative Body Burden of estrogen-3,4-quinone in Breast Cancer Patients and Controls Using Albumin Adducts as Biomarkers

Che Lin, Dar-Ren Chen, Wei-Chung Hsieh, Wen-Fa Yu, Ching-Chiuan Lin, Mao-Huei Ko, Chang-Hsin Juan, Ben-Jei Tsuang, Po-Hsiung Lin

Toxicol Lett. 2013 Apr 26;218(3):194-9.

PMID: 23422263

Abstract:

Both 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q) are reactive metabolites of estrogen. Elevation of E2-3,4-Q to E2-2,3-Q ratio is thought to be an important indicator of estrogen-induced carcinogenesis. Our current study compared the cumulative body burden of these estrogen quinones in serum samples taken from Taiwanese women with breast cancer (n=152) vs healthy controls (n=75) by using albumin (Alb) adducts as biomarkers. Results clearly demonstrated the presence of cysteinyl adducts of E2-2,3-Q-4-S-Alb and E2-3,4-Q-2-S-Alb in all study population at levels ranging from 61.7-1330 to 66.6-1,590 pmol/g, respectively. Correlation coefficient between E2-2,3-Q-4-S-Alb and E2-3,4-Q-2-S-Alb was 0.610 for controls and 0.767 for breast cancer patients (p<0.001). We also noticed that in premenopausal subjects with body mass index (BMI) less than 27, background levels of E2-3,4-Q-2-S-Alb was inversely proportional to BMI with about 25% increase in E2-3,4-Q-2-S-Alb per 5 kg/m(2) decrease in BMI (p<0.001). In addition, we confirmed that mean levels of E2-3,4-Q-2-S-Alb in breast cancer patients were ∼5-fold greater than in those of controls (p<0.001). Overall, this evidence suggests that disparity in estrogen disposition and the subsequent elevation of cumulative body burden of E2-3,4-Q may play a role in the development of breast cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1261254481-B	17β-Estradiol-2,3,4-13C3		1261254-48-1	Price

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