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Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception

Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception

Flávia Franceli de Brito Passos, Everton Moraes Lopes, Jonas Moura de Araújo, Damião Pergentino de Sousa, Leiz Maria C Veras, José Roberto S A Leite, Fernanda Regina de Castro Almeida

Evid Based Complement Alternat Med. 2015;2015:829414.

PMID: 26170885

Abstract:

The literature shows that the monoterpenes are great candidates for the development of new drugs for the treatment of various pathological processes, including painful conditions. The gamma terpinene (γ-TPN) is a monoterpene present in plant species that have multiple pharmacological properties and has structural similarity to antinociceptive monoterpenes, such as limonene and alpha-phellandrene. The γ-TPN molecular mass was evaluated by mass spectrometry and showed a pseudomolecular ion with m/z 137.0 Da. The animals did not present any signs of acute toxicity at 2 g/kg, p.o. γ-TPN (1.562 to 50 mg/kg, p.o.) showed an antinociceptive effect in the formalin, capsaicin, and glutamate tests. γ-TPN has antinociceptive action when administered by others routes in glutamate test. To eliminate a possible sedative effect of γ-TPN, the open field and rota-rod test were conducted and the γ-TPN did not show muscle relaxant activity or central depressant effect. To investigate the mechanisms of action, the animals were pretreated with naloxone, glibenclamide, atropine, mecamylamine, or L-arginine in the glutamate test. γ-TPN antinociception was inhibited in the presence of naloxone, glibenclamide, atropine, and mecamylamine. The results suggest that the γ-TPN (p.o.) produced antinociceptive effect in models of chemical nociception through the cholinergic and opioid systems involvement.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP99854	γ-Terpinene		99-85-4	Price

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