Home
Resources
Publications
Involvement of Mitochondrial Apoptotic Pathway and MAPKs/NF-κ B Inflammatory Pathway in the Neuroprotective Effect of Atractylenolide III in Corticosterone-Induced PC12 Cells

Involvement of Mitochondrial Apoptotic Pathway and MAPKs/NF-κ B Inflammatory Pathway in the Neuroprotective Effect of Atractylenolide III in Corticosterone-Induced PC12 Cells

Wen-Xia Gong, Yu-Zhi Zhou, Xue-Mei Qin, Guan-Hua DU

Chin J Nat Med. 2019 Apr;17(4):264-274.

PMID: 31076130

Abstract:

Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromocytoma (PC12) cells. Our results demonstrate that ATL-III increases cell viability and reduces the release of lactate dehydrogenase (LDH). The results suggest that ATL-III protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca2+ overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF-ΚB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-III protected the PC12 cells against corticosterone-induced injury for the first time. Our results provide the evidence that ATL-III may serve as a therapeutic agent in the treatment of depression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP73030714	Atractylenolide III		73030-71-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: