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Iodination and Radiolabeling of Alpha-Allocryptopine With iodine-125

Yu Wei, Xionghui Wei, Yi Wang, Xinqi Liu, Taiwei Chu, Shaowen Hu, Xiangyun Wang

Appl Radiat Isot. 2005 Jan;62(1):55-62.

PMID: 15498685

Abstract:

A procedure for labeling of alpha-allocryptopine with 125I is reported in this article. Alpha-allocryptopine is first iodinated with largely excessive iodine monochloride, and then radiolabeled by isotopic exchange with Na125I in a dichloromethane-water two-phase system. The radiochemical purity and yield of the labeled product are typically as high as 94% and 72%, respectively. Further chromatographic purification gives a highly pure product (radiochemical purity > 99%). The distribution of 125I-labeled alpha-allocryptopine in mice at 2 h after injection shows that the uptake of radioiodine in thyroid is negligibly low.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP485916 α-Allocryptopine α-Allocryptopine 485-91-6 Price
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