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Ionophoretic-like Properties of Ketorolac for Calcium

Ionophoretic-like Properties of Ketorolac for Calcium

R Chàvez, C Bravo, C Zazueta, J Pichardo, A Uribe, N Corona, H Reyes-Vivas, C González, E Chàvez

J Pharmacol Exp Ther. 1993 Dec;267(3):1134-9.

PMID: 7505327

Abstract:

Ketorolac is an analgesic drug known to induce its therapeutic effect by inhibiting prostaglandin synthesis. In this work we introduce the nonsteroidal antialgesic drug as a compound with ionophoretic properties for calcium ions, showing that ketorolac induces mitochondrial Ca++ release. This reaction did not depend on an uncoupler-like action, because the drug does not collapse the internal negative membrane potential nor does it affect oxidative phosphorylation. In addition, it is shown that ketorolac ferries calcium ions into energized liposomes and has a hydrophobic phase with an affinity constant of 4 x 10(-3). The therapeutic action of ketorolac is related to its ionophoretic properties in addition to its well known inhibitory effect on the cyclooxygenase enzyme.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP113502559	Ketorolac Related Compound D		113502-55-9	Price

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