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IR-783-Glucosamine

IR-783-Glucosamine

Kam Leung

PMID: 20641727

Abstract:

Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets (1-3). However, the intrinsic fluorescence of biomolecules poses a problem when fluorophores that absorb visible light (350-700 nm) are used. Near-infrared (NIR) fluorescence (700-1,000 nm) detection avoids the background fluorescence interference of natural biomolecules, providing a high contrast between target and background tissues in small animals. NIR fluorophores have a wider dynamic range and minimal background as a result of reduced scattering compared with visible fluorescence detection. They also have high sensitivity, resulting from low fluorescence background, and high extinction coefficients, which provide high quantum yields. The NIR region is also compatible with solid-state optical components, such as diode lasers and silicon detectors. NIR fluorescence imaging is becoming a non-invasive alternative to radionuclide imaging in small animals (4, 5).
Lysosomes are membranous vesicles found in most mammalian cells (6). Lysosomes contain various types of proteases, which have been implicated in migration, invasion, and metastasis of malignant cancer cells by the degradation of extracellular matrix (7). Glucosamine is used to synthesize highly glycosylated lysosomal proteins (8). The sizes of lysosomes are found to be larger in malignant cancer cells than in benign cancer cells (9). Carbocyanine IR-783 was conjugated to glucosamine for imaging lysosomal content in tumors with NIR fluorescence (10, 11).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP115970666	IR-783		115970-66-6	Price

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