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Irinotecan Hydrochloride Trihydrate Loaded Folic Acid-Tailored Solid Lipid Nanoparticles for Targeting Colorectal Cancer: Development, Characterization, and

Irinotecan Hydrochloride Trihydrate Loaded Folic Acid-Tailored Solid Lipid Nanoparticles for Targeting Colorectal Cancer: Development, Characterization, and

Kuldeep Rajpoot, Sunil K Jain

J Microencapsul. 2019 Nov;36(7):659-676.

PMID: 31495238

Abstract:

Aim: The aim of this investigation was to evaluate the potential of folic acid-tailored solid lipid nanoparticles (SLNs) for encapsulation as well as for in vitro cytotoxicity study of irinotecan hydrochloride trihydrate (IHT) against colorectal cancer (CRC) by using HT-29 cells. Methods: Solvent diffusion technique was employed for the preparation of SLNs. Further, the formulations were optimised via three-level, three-factor Box-Behnken design (BBD). Results: The uncoupled SLNs (IRSLNs) and folic acid-coupled SLNs (IRSLNFs) formulations revealed not only high %entrapment efficiency but also small particle size. Moreover, in vitro drug release results from IRSLNs and IRSLNFs confirmed that they followed sustained-release effect for up to 144 h. Whereas, in vitro cell viability study against HT-29 cell line suggested significantly (p < 0.05) higher cytotoxicity (IC50 = 15 µg/ml) of IRSLNFs over IRSLNs and IHT solution. Conclusions: Outcomes suggested that the engineered IRSLNFs hold great potential for targeting CRC for an extended period of time.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP1173021890	Difloxacin-d3 hydrochloride trihydrate		1173021-89-0 (anhydrous)	Price
AS211203	Sarafloxacin-d8 hydrochloride trihydrate			Price

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