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Irinotecan/IR-820 Coloaded Nanocomposite as a Cooperative Nanoplatform for Combinational Therapy of Tumor

Irinotecan/IR-820 Coloaded Nanocomposite as a Cooperative Nanoplatform for Combinational Therapy of Tumor

Tingting Li, Xue Shen, Xiaoxue Xie, Zhongyuan Chen, Shun Li, Xiang Qin, Hong Yang, Chunhui Wu, Yiyao Liu

Nanomedicine (Lond). 2018 Mar 1;13(6):595-603.

PMID: 29381122

Abstract:

Aim:
To enhance synergistic therapeutic effects in breast cancer therapy. Here, we used hollow mesoporous silica nanoparticles as a biocompatible carrier to coload chemotherapy drugs Irinotecan and near-infrared IR-820 dye, which enhanced antitumor efficacy by combining chemotherapy and phototherapy.
Methods:
The successful synthesis of hollow mesoporous silica nanoparticles/Irinotecan/IR820 (HMII) nanocomplex was confirmed by Fourier transform infrared spectroscopy and Fluorescence spectra. The photothermal conversion efficiency and antitumor efficiency in murine breast cancer cells (EMT-6) bearing mice were further evaluated.
Results:
The results demonstrated that HMII enhanced the delivery of Irinotecan and IR-820 into EMT-6 cells. HMII generated a high temperature upon a near-infrared laser irradiation (808 nm), and showed higher therapeutic efficacy in EMT-6-bearing mice compared with either HMII without laser or free drug with a laser.
Conclusion:
HMII is a desired drug codelivery system to efficiently inhibit the growth of breast cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP172616807	IR-820		172616-80-7	Price

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