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Iron Carbonyl-Mediated Parallel Solution-Phase Synthesis of Cyclohexadienoic Acid Amides

Henrik Gradén, Jesper Hallberg, Nina Kann, Thomas Olsson

J Comb Chem. Sep-Oct 2004;6(5):783-8.

PMID: 15360214

Abstract:

Iron carbonyl-stabilized cations have been employed to develop methodology for carbon-carbon and carbon-heteroatom formation suitable for the preparation of combinatorial libraries. Different nucleophiles were added to tricarbonyl(cyclohexa-1,3-dienylcarboxylic acid 4-nitro-phenyl ester)iron hexafluorophosphate. Aminolysis, followed by decomplexation, yielded substituted cyclohexadienyl amides of high purity. Carbon, oxygen, and sulfur nucleophiles gave good results, while amine nucleophiles gave products of somewhat lower purity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP51508599 Tricarbonyl(2-methoxycyclohexadienylium) iron hexafluorophosphate Tricarbonyl(2-methoxycyclohexadienylium) iron hexafluorophosphate 51508-59-9 Price
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