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Iron Oxide Magnetic Nanoparticles With Versatile Surface Functions Based on Dopamine Anchors

Iron Oxide Magnetic Nanoparticles With Versatile Surface Functions Based on Dopamine Anchors

Mykola Mazur, Alexandre Barras, Victor Kuncser, Andrei Galatanu, Vladimir Zaitzev, Kostiantyn V Turcheniuk, Patrice Woisel, Joel Lyskawa, William Laure, Aloysius Siriwardena, Rabah Boukherroub, Sabine Szunerits

Nanoscale. 2013 Apr 7;5(7):2692-702.

PMID: 23420060

Abstract:

The synthesis of multifunctional magnetic nanoparticles (MF-MPs) is one of the most active research areas in advanced materials as their multifunctional surfaces allow conjugation of biological and chemical molecules, thus making it possible to achieve target-specific diagnostic in parallel to therapeutics. We report here a simple strategy to integrate in a one-step reaction several reactive sites onto the particles. The preparation of MF-MPs is based on their simultaneous modification with differently functionalized dopamine derivatives using simple solution chemistry. The formed MF-MPs show comparable magnetic properties to those of naked nanoparticles with almost unaltered particle size of around 25 nm. The different termini, amine, azide and maleimide functions, enable further functionalization of MF-MPs by the grafting-on approach. Michael addition, Cu(i) catalyzed « click » chemistry and amidation reactions are performed on the MF-MPs integrating subsequently 6-(ferrocenyl)-hexanethiol, horseradish peroxidase (HRP) and mannose.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR424824	Peroxidase, Maleimide Activated from horseradish			Price

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