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Is There a Halo-Enzymopathy in Parkinson's Disease?

Is There a Halo-Enzymopathy in Parkinson's Disease?

E Fernández-Espejo

Neurologia. 2019 Apr 2;S0213-4853(19)30026-X.

PMID: 30952477

Abstract:

Laboratory studies identified changes in the metabolism of halogens in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease, which indicates the presence of «accelerated self-halogenation» of CSF and/or an increase in haloperoxidases, specifically serum thyroperoxidase and CSF lactoperoxidase. Furthermore, an excess of some halogenated derivatives, such as advanced oxygenation protein products (AOPP), has been detected in the CSF and serum. «Accelerated self-halogenation» and increased levels of haloperoxidases and AOPP proteins indicate that halogenative stress is present in Parkinson's disease. In addition, 3-iodo-L-tyrosine, a halogenated derivative, shows «parkinsonian» toxicity in experimental models, since it has been observed to induce α-synuclein aggregation and damage to dopaminergic neurons in the mouse brain and intestine. The hypothesis is that patients with Parkinson's disease display halogenative stress related to a haloenzymatic alteration of the synthesis or degradation of oxyacid of halogens and their halogenated derivatives. This halogenative stress would be related to nervous system damage.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70780	3-Iodo-L-tyrosine		70-78-0	Price

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