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Isoeugenol Is an Important Contact Allergen: Can It Be Safely Replaced With Isoeugenyl Acetate?

Isoeugenol Is an Important Contact Allergen: Can It Be Safely Replaced With Isoeugenyl Acetate?

I R White, J D Johansen, E G Arnau, J P Lepoittevin, S Rastogi, M Bruze, K E Andersen, P J Frosch, A Goossens, T Menné

Contact Dermatitis. 1999 Nov;41(5):272-5.

PMID: 10554062

Abstract:

The prevalence of contact allergy to the fragrance mix in individuals with eczema is up to 10%. Within the mix, isoeugenol (CAS 97-54-1) is an important individual allergen. Until May 1998, the IFRA (International Fragrance Association) guidelines suggested that isoeugenol could safely be used at a level of 0.2% in consumer products. In May 1998, IFRA recommended that isoeugenol should not be used at a level that exceeds 0.02% in consumer products, but did not provide guidance on allergen substitution. An alternative to isoeugenol, based on aroma and absence of guidelines on use, is isoeugenyl acetate (CAS 93-29-8). 155 consecutive subjects were patch tested to isoeugenyl acetate (1.2%, 0.4%, 0.13% eth.) and isoeugenol 1% pet. 6 (3.9%) had an allergic reaction to 1.2% isoeugenyl acetate at D4. The reactions to the other 2 dilutions tended to be graded. 8 individuals had at least a palpable erythema by D4 to isoeugenol 1% pet. The majority of individuals allergic to isoeugenol were also intolerant of isoeugenyl acetate. Effective labelling of fragrance substances on consumer products will facilitate monitoring of exposure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP93298	Isoeugenyl acetate		93-29-8	Price

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