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Isolated Branched-Chain Amino Acid Intake and Muscle Protein Synthesis in Humans: A Biochemical Review

Isolated Branched-Chain Amino Acid Intake and Muscle Protein Synthesis in Humans: A Biochemical Review

Carina de Sousa Santos, Fabrício Expedito Lopes Nascimento

Einstein (Sao Paulo). 2019 Sep 5;17(3):eRB4898.

PMID: 31508659

Abstract:

Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS24713	6-Ring NOGE (Novolac glycidyl ether) mixture of isomers, chain-like or branched			Price

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