Home
Resources
Publications
Isolation and Identification of Two Unknown Impurities From the Raw Material of Clindamycin Hydrochloride

Isolation and Identification of Two Unknown Impurities From the Raw Material of Clindamycin Hydrochloride

Qiushi Sun, Yue Li, Li Qin

J Sep Sci. 2014 Oct;37(19):2682-7.

PMID: 25044425

Abstract:

Clindamycin hydrochloride belongs to the antibiotic family of lincomycin. It has the same antibacterial spectrum as lincomycin, but the antibacterial activity is four to eight times stronger than that of lincomycin. There have been some adverse reactions in clinical use of clindamycin hydrochloride and its finished drug products. The impurities in drugs are directly related to their safety. In this study, two unknown impurities were isolated from the raw material of clindamycin hydrochloride through various chromatographic methods. Their structures were identified as clindamycin isomer (impurity 1) and dehydroclindamycin (impurity 2) by mass spectrometry and NMR spectroscopy. Both of them were found for the first time. The two impurities exhibit a similar but lower antibacterial activity compared with clindamycin hydrochloride.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP58207195	Clindamycin hydrochloride		58207-19-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: