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Isolation and Nucleotide Sequence of the Aspergillus Restrictus Gene Coding for the Ribonucleolytic Toxin Restrictocin and Its Expression in Aspergillus Nidulans: The Leader Sequence Protects Producing Strains From Suicide

Isolation and Nucleotide Sequence of the Aspergillus Restrictus Gene Coding for the Ribonucleolytic Toxin Restrictocin and Its Expression in Aspergillus Nidulans: The Leader Sequence Protects Producing Strains From Suicide

B Lamy, J Davies

Nucleic Acids Res. 1991 Mar 11;19(5):1001-6.

PMID: 2020539

Abstract:

We describe the cloning and characterization of the gene coding for the ribotoxin restrictocin, from Aspergillus restrictus (gene res, EMBL accession Number X56176). This toxin is a potent inhibitor of protein synthesis in eucaryotes and is of potential interest as a component of immunotoxins. To analyze the mechanism of self-protection in the producing organism, the res gene was cloned into the vector pFB39 and introduced into Aspergillus nidulans. The secretion of active restrictocin from transformants suggests that the pro-toxin is not an active nuclease but is activated during the process of secretion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1406720	Restrictocin from Aspergillus restrictus		1406-72-0	Price

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