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[Isolation and Structural Elucidation of Secondary Metabolites From Marine Streptomyces Sp. SCSIO 1934]

[Isolation and Structural Elucidation of Secondary Metabolites From Marine Streptomyces Sp. SCSIO 1934]

Siwen Niu, Sumei Li, Xinpeng Tian, Tao Hu, Jianhua Ju, Xiaohong Ynag, Si Zhang, Changsheng Zhang

Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(13):1763-8.

PMID: 22032140

Abstract:

Marine Actinobacteria are emerging as new resources for bioactive natural products with promise in novel drug discovery. In recent years, the richness and diversity of marine Actinobacteria from the South China Sea and their ability in producing bioactive products have been investigated. The objective of this work is to isolate and identify bioactive secondary metabolites from a marine actinobacterium SCSIO 1934 derived from sediments of South China Sea. The strain was identified as a Streptomyces spieces by analyzing its 16S rDNA sequence. Streptomyces sp. SCSIO 1934 was fermented under optimized conditions and seven bioactive secondary metabolites were isolated and purified by chromatographic methods including colum chromatography over silica gel and Sephadex LH-20. Their structures were elucidated as 17-O-demethylgeldanamycin (1), lebstatin (2), 17-O-demethyllebstatin (3), nigericin (4), nigericin sodium salt (5), abierixin (6), respectively, by detailed NMR spectroscopic data (1H, 13C, COSY, HSQC and HMBC). This work provided a new marine actinobacterium Streptomyces sp. SCSIO 1934, capable of producing diverse bioactive natural products.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28643803-A	Nigericin sodium salt		28643-80-3	Price

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