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Isolation and Structure Determination of a New Lantibiotic Cinnamycin B From Actinomadura Atramentaria Based on Genome Mining

Isolation and Structure Determination of a New Lantibiotic Cinnamycin B From Actinomadura Atramentaria Based on Genome Mining

Shinya Kodani, Hisayuki Komaki, Sho Ishimura, Hikaru Hemmi, Mayumi Ohnishi-Kameyama

J Ind Microbiol Biotechnol. 2016 Aug;43(8):1159-65.

PMID: 27255974

Abstract:

New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695(T), based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule. Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0.5μL, 10 mg/mL solution) at spot-on-lawn testing method. The gene cluster of cinnamycin B on the genome of A. atramentaria was identified and discussed in comparison with that of cinnamycin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP110655588	Cinnamycin		110655-58-8	Price

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