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Isolation of a New Compound, 2-butanone 4-glucopyranoside 6'-O-gallate and Other 8 Compounds From the Anti-Inflammatory Leave Extracts of Memecylon Edule Roxb

Isolation of a New Compound, 2-butanone 4-glucopyranoside 6'-O-gallate and Other 8 Compounds From the Anti-Inflammatory Leave Extracts of Memecylon Edule Roxb

Somsak Nualkaew, Suchitra Thongpraditchote, Yuwadee Wongkrajang, Kaoru Umehara, Hiroshi Noguchi

Nat Prod Res. 2017 Jun;31(12):1370-1378.

PMID: 27820960

Abstract:

This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6'-O-gallate (1) with eight known compounds, namely, 3,3'-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)-dihydromyricetin-4'-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9). All compounds were isolated for the first time from this plant. The major compounds (2, 3 and 5) exhibited significant anti-inflammatory activity. In conclusion, M. edule was recognised to be a good source for phenolic compounds and these compounds may contribute to anti-inflammatory activity of the extract.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410452	(±)-Gallocatechin-2,3,4-13C3 gallate			Price

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