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Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo, Hoon Kim, Hyeon-Son Choi, Seung-Su Lee, Myun-Ho Bang, Hyung Joo Suh

Food Sci Biotechnol. 2018 Jul 13;27(6):1833-1842.

PMID: 30483448

Abstract:

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26545744	Glyceryl monolinoleate		26545-74-4	Price

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