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Isolation of the New Anacardic Acid 6-[16'Z-nonadecenyl]-salicylic Acid and Evaluation of Its Antimicrobial Activity Against Streptococcus Mutans and Porphyromonas Gingivalis

Isolation of the New Anacardic Acid 6-[16'Z-nonadecenyl]-salicylic Acid and Evaluation of Its Antimicrobial Activity Against Streptococcus Mutans and Porphyromonas Gingivalis

Blanca E Rivero-Cruz, Nuria Esturau, Sobeida Sánchez-Nieto, Irma Romero, Israel Castillo-Juárez, J Fausto Rivero-Cruz

Nat Prod Res. 2011 Aug;25(13):1282-7.

PMID: 21815722

Abstract:

A new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds, 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0) (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4), masticadienonic acid (5), 3α-hydroxymasticadienonic acid (6), 3-epi-oleanolic acid (7) and β-sitosterol, were isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method. The structure of the new compound (1) was elucidated by spectroscopic data interpretation. The known compounds (2-7) were identified by comparison of their spectroscopic data with reported values in the literature. Compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL, respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16611840-A	(15:0)-Anacardic acid		16611-84-0	Price

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