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Isomerization of Prostaglandin H2 Into Prostaglandin D2 in the Presence of Serum Albumin

Isomerization of Prostaglandin H2 Into Prostaglandin D2 in the Presence of Serum Albumin

M Hamberg, B B Fredholm

Biochim Biophys Acta. 1976 Apr 22;431(1):189-83.

PMID: 1268242

Abstract:

The prostaglandin endoperoxide, prostaglandin H2, decomposes in aqueous media mainly into prostaglandin E2. This paper shows that in the presence of serum albumin from a number of species prostaglandin H2 decomposes mainly into prostaglandin D2, an isomer of prostaglandin E2. The effect on endoperoxide decomposition exerted by serum albumin may well have physiological significance since intace endoperoxides can be released from tissues and since the biological properties of prostaglandins E2 and D2 are quite different.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP42935171	Prostaglandin H2		42935-17-1	Price

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