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Isorhamnetin: A Hepatoprotective Flavonoid Inhibits Apoptosis and Autophagy via P38/PPAR-α Pathway in Mice

Isorhamnetin: A Hepatoprotective Flavonoid Inhibits Apoptosis and Autophagy via P38/PPAR-α Pathway in Mice

Xiya Lu, Tong Liu, Kan Chen, Yujing Xia, Weiqi Dai, Shizan Xu, Ling Xu, Fan Wang, Liwei Wu, Jingjing Li, Sainan Li, Wenwen Wang, Qiang Yu, Jiao Feng, Xiaoming Fan, Yingqun Zhou, Peiqin Niu, Chuanyong Guo

Biomed Pharmacother. 2018 Jul;103:800-811.

PMID: 29684859

Abstract:

Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously. The serum and liver tissues were harvested at 2, 8, and 24 h after ConA injection. The levels of serum liver enzymes and proinflammatory cytokines were significantly reduced in isorhamnetin administration groups. Besides, isorhamnetin improved pathological damage. Furthermore, isorhamnetin affected P38/PPAR-α pathway, and subsequently regulated the expression of apoptosis and autophagy related proteins. The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP480193-A	Isorhamnetin		480-19-3	Price

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