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Isosorbide

Suryakumar Balasubramanian, Yuvraj S. Chowdhury

PMID: 32491771

Abstract:

Porje initiated the research on isosorbide in Stockholm, and the drug was marketed in Sweden in 1946. Isosorbide dinitrate was synthesized in the United States in the 1950s by Harris and colleagues. After the introduction of isosorbide, its popularity temporarily decreased as Needleman and his colleagues questioned the efficacy of isosorbide as it underwent extensive biotransformation in the liver. This opinion changed after a few years, and now it gained worldwide acceptance. Isosorbide belongs to the nitrate group of medications that acts by releasing nitric oxide (N0), thereby causing vasodilation. Isosorbide is available in two forms as isosorbide mononitrate and isosorbide dinitrate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
CS31041970 Isosorbide Isosorbide Price
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