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Itraconazole-loaded Micelles Based on Linear-Dendritic Poly (Ethylene Glycol)-B-Poly (ε-caprolactone)

Itraconazole-loaded Micelles Based on Linear-Dendritic Poly (Ethylene Glycol)-B-Poly (ε-caprolactone)

Shida Li, Wenxiu Wei, Weiping Jia, Lechen Zhao, Hongmei Xu, Feilong Zhou, Li Zhu, Zhimei Song, Sijia Feng, Runliang Feng

J Biomater Sci Polym Ed. 2018 Dec;29(18):2299-2311.

PMID: 30485754

Abstract:

A copolymeric micelle formulation of itraconazole (ITR-M) was prepared using linear-dendritic monoallyloxy poly (ethylene glycol)-b-poly (ε-caprolactone) (APEG-PCL) as drug carrier materials. DL and EE values of ITR-M were 5.70 ± 0.12% and 91.30 ± 1.90%, respectively. The micelle formulation enhanced the ITR solubility up to 30.42 μg/mL. In vitro release of ITR from the ITR-M was mainly drug diffusion process followed by the copolymer's degradation. ITR-M showed similar anti-Candida albicans activity to that of crude ITR although its release of ITR was slow and continuous. The in vivo pharmacokinetic study demonstrated that the ITR-M could improve tissue distribution of ITR. In conclusion, APEG-PCL could be a potential carrier in the development of antifungal drug delivery system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74342	Poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone)			Price

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