0

Ixodes Scapularis: Salivary Kininase Activity Is a Metallo Dipeptidyl Carboxypeptidase

J M Ribeiro, T N Mather

Exp Parasitol. 1998 Jun;89(2):213-21.

PMID: 9635445

Abstract:

Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment 1-7 and 1-5 as being produced subsequent to incubation of purified salivary kininase with bradykinin. The activity was inhibited by captopril and EDTA and was activated by cobalt and manganese, a behavior similar to that displayed by angiotensin-converting enzymes of vertebrate and invertebrate origins.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23815874 Bradykinin Fragment 1-7 Bradykinin Fragment 1-7 23815-87-4 Price
qrcode