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Jeju Ground Water Containing Vanadium Induces Normal T Cell Development and Immune Activation in Chronically Stressed Mice

Jeju Ground Water Containing Vanadium Induces Normal T Cell Development and Immune Activation in Chronically Stressed Mice

Jinhee Cho, So Jin Bing, Areum Kim, Kalahe Hewage Iresha Nadeeka Madushani Herath, Ginnae Ahn, Youngheun Jee

Mol Biol Rep. 2019 Aug;46(4):4443-4452.

PMID: 31302805

Abstract:

Containing high concentration of vanadium served by the volcanic bedrock, Jeju ground water has long been known for various implicit health benefits including immune-promotion. Exposure to stress has been reported to be associated with immunosuppression such as reducing lymphocyte population or antibody production due to stress hormones. In this study, we aimed at evaluating the effects of Jeju ground water on chronically stressed mice. C57BL/6 mice were subjected to various stressors such as restraint stress, water swimming stress, heat stress, acoustic stress, and Jeju ground water was supplied for 28 days with two different concentrations, S1 (vanadium 15-20 μg/l, pH 8.3) and S2 (vanadium 20-25 μg/l, pH 8.5). Treatment with Jeju ground water increased CD4+CD8- or CD4-CD8+ single-positive thymocytes. It also increased the proliferation of splenocytes and the populations of CD4+ T cells, CD45R/B220+ B cells, CD11b+ macrophages or Gr-1+ granulocytes in spleen. In addition, the production of IgG was increased in chronically stressed mice by treatment with Jeju ground water. These results suggest vanadium-rich Jeju ground water may be helpful in T cell development in thymus and immune cell proliferation and its function in spleen against chronic stress.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS3104390	Ground water			Price

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