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JTC-801 Inhibits the Proliferation and Metastasis of the Hep G2 Hepatoblastoma Cell Line by Regulating the Phosphatidylinositol 3-kinase/protein Kinase B Signalling Pathway

JTC-801 Inhibits the Proliferation and Metastasis of the Hep G2 Hepatoblastoma Cell Line by Regulating the Phosphatidylinositol 3-kinase/protein Kinase B Signalling Pathway

Bufei Zhao, Ting Hu

Oncol Lett. 2019 Feb;17(2):1939-1945.

PMID: 30675258

Abstract:

The increased worldwide mortality rate due to liver cancer may be attributed to the aggressive nature of the disease. Signal transduction through G-protein-coupled receptors (GPCRs) can affect a number of aspects of cancer biology, including invasion, migration and vascular remodelling. JTC-801, a novel GPCR antagonist, has demonstrated promising anticancer effects in adenocarcinoma and osteosarcoma cells. In the present study, the effect of JTC-801 on the proliferation and migration of hepatoblastoma Hep G2 cells was investigated. The Cell Counting Kit-8 assay revealed that JTC-801 markedly suppressed the growth of the Hep G2 cells. Additionally, JTC-801 significantly inhibited cell invasion and migration in a Transwell assay. Furthermore, the expression of anti-apoptotic protein B-cell lymphoma 2 decreased and the expression of the pro-apoptotic proteins active caspase-3 and apoptosis regulator BAX increased in the Hep G2 cells following JTC-801 treatment. Additionally, JTC-801 suppressed the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signalling pathway in the Hep G2 cells. Therefore, the present study revealed that JTC-801 can induce the apoptosis of Hep G2 cells by regulating the PI3K/AKT signalling pathway, which suggests that JTC-801 may be a potential novel drug target for clinical liver cancer treatment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP244218517	JTC-801		244218-51-7	Price

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